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neurophysiology > neurophysiology study 4
Neurophysiology
and Intelligence Study #4
Title
Antioxidant Properties of Two Ayurvedic Herbal Preparations
(MAK-4 and MAK-5)
Publication
Biochemical Archives, Vol. 10, pp. 25-31, 1994.
Authors
Stephen C. Bondy, Tina M. Hernandez, and Cara Mattia.
Conducted at
Department of Community and Environmental Medicine,
University of California (IIrvine), Irvine, CA 92717
Summary
This study investigated the antioxidant effects of MAK-4
and MAK-5 in the rat brain in vitro and in vivo. In
vitro, ethanol and aqueous extracts of MAK-4 and MAK-5
were able to quench generation of reactive oxygen species
within an isolated fraction of rat cerebral cortex enriched
in mitochondria and nerve endings (synaptosomes).
In
vivo, the excess production of reactive oxygen species
observed within the cerebellar mitochondrial fraction
after exposure of rats to toluene, was prevented by
pretreatment with MAK-5.
For
more information on this study, see Research on Reduction
of Chemical Toxicity and Antioxidant Research.
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