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antioxidant research > antioxidant study 11
Antioxidant Study #11
Title
The Antioxidant and Antiatherogenic Effects of MAK-4
in WHHL Rabbits
Publication
Journal of Alternative and Complementary Medicine,
Vol. 2, No. 4, pp. 463-478, 1996.
Authors
Jae Y. Lee, PhD, Atef N. Hanna, PhD, John A. Lott,
PhD, and Hari M. Sharma, MD, FRCPC.
Conducted
at
Department of Pathology, College of Medicine, The
Ohio State University, Columbus, OH 43210
Summary
This study tested the effect of MAK-4 on the development
of atheroma in WHHL rabbits. Eleven rabbits were divided
into two groups: controls (n = 5) and a group fed
6% (w/w) MAK-4 (n = 6). Blood was drawn for biochemical
analysis every two months and at necropsy, six months
after the special diet was started. The aortas were
preserved in formalin. The percentage area of aortic
arch covered with visible plaque in the MAK-4 group
(22.5 ± 4.2%, mean ± SE) was significantly
reduced (p <0.01) compared to the control group
(47.6 ± 6.8%, mean ± SE). The MAK-4
group showed a significant decrease (p <0.05) in
lipid peroxide, and a significant increase (p <0.05)
in glutathione peroxidase and resistance of LDL to
endothelial cell-induced and cupric ion-catalyzed
oxidation (4.5 h and 5 h lag phase, respectively,
for the MAK-4 group; 0 h lag phase for both for the
controls). These findings suggest MAK-4 reduces atheroma
formation through its antioxidant activity. See Cardiovascular
Research for more information on this study.
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