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antioxidant research > antioxidant study 10
Antioxidant Study #10
Title
Inhibition of Low-Density Lipoprotein Oxidation
by Oral Herbal Mixtures Maharishi Amrit Kalash-4
(MAK-4) and Maharishi Amrit Kalash-5 (MAK-5) in
Hyperlipidemic Patients
Publication
The
American Journal of the Medical Sciences, Vol. 314,
No. 5, pp. 303-310, 1997.
Authors
Vidya Sundaram, M.D.,* Atef N. Hanna, Ph.D.,** Gary
P. Lubow, M.D.,** Lata Koneru, M.D.,Ú James M. Falko,
M.D.,* and Hari M. Sharma, M.D.**
Conducted
at
*Department of Internal Medicine and **Department
of Pathology, College of Medicine, The Ohio State
University, Columbus, OH
ÚDepartment of Internal Medicine, Riverside Methodist
Hospital, Columbus, OH.
Summary
Low-density lipoprotein (LDL) oxidation is central
to the pathogenesis of atherosclerosis. This study
evaluated the antioxidant activity of MAK-4 and
MAK-5 in vivo. Ten hyperlipidemic patients prescribed
stable hypolipidemic therapy were treated with MAK-4
and MAK-5 for 18 weeks. Plasma lipoprotein, plasma
lipid peroxide, and LDL oxidation studies were performed
every 6 weeks. Apolipoprotein A, apolipoprotein
B, and lipoprotein (a) levels were measured at baseline
and 18 weeks. After 12 weeks of treatment with MAK-4
and MAK-5, a time-dependent increase in the lag
phase and delay in the propagation phase of oxidation
of LDL by Cu+2 and endothelial cells was seen. Lag
phases at baseline and after 6, 12, and 18 weeks
of MAK-4 and MAK-5 ingestion were 6.66 hours ±
0.19 (mean ± standard error of mean), 6.77
hours ± 0.31, 7.22 hours ± 0.24, and
18.00 hours ± 0.73, respectively, for Cu+2-catalyzed
LDL oxidation. Lag phases were 14.89 hours ±
0.77, 13.33 hours ± 0.50, 20.22 hours ±
0.76, and 20.00 hours ± 0.79, respectively,
for endothelial cell-induced LDL oxidation. The
levels of plasma lipid peroxide did not change significantly.
No significant changes were seen in the plasma lipoproteins
and the levels of apolipoprotein A, apolipoprotein
B, and lipoprotein (a). The results show that MAK-4
and MAK-5 inhibit LDL oxidation in patients with
hyperlipidemia. Therefore, MAK-4 and MAK-5 may be
useful in the prevention and treatment of atheroslerosis.
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