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antioxidant research > antioxidant study 21
Antioxidant Study #21
Title
Lipid Peroxide in Ischemic Heart Disease (IHD): Inhibition by Maharishi Amrit Kalash (MAK-4 and MAK-5) Herbal Mixtures
Publication
Federation of the American Societies for Experimental Biology Journal, Vol. 14, No. 4, p. A121, 2000 (Abstract).
Authors
J. Dogra and A. Bhargava (SPON: H. Sharma).
Conducted at
Central Government Health Scheme and Okay Research Centre, Jaipur, India 302017
Summary
As oxidation of low-density lipoprotein plays a significant role in atherogenesis, an improvement in the antioxidant status should lead to a protective effect. We initiated this trial to study the in vivo effects of MAK-4 and MAK-5 (herbal mixtures containing polyphenols, bioflavonoids, tocopherol, ascorbic acid, and carotenoids) on lipid peroxide in addition to its clinical efficacy. Eighty patients with proven IHD were enrolled in our study. Lipid peroxide studies were done initially and at one year in MAK-supplemented and control groups. The control group consisted of 40 IHD patients minus MAK. Drugs like antioxidant vitamin E and lipid-lowering agents were withdrawn in both groups. Clinical parameters of drug responses were assessed. MAK-4 paste was described in a dose of 10 g daily in 2 divided doses followed by MAK-5 tablet, for 1 year as ‘add-on’ regimen. Thirty-four patients reported a significant decrease in the mean anginal frequency per month from 5.50 (+3.20) to 2.15 (+2.00) and improvement in the treadmill test was reported in 8 cases at 1 year. Echocardiography studies reported improvement in ejection fraction in 7 cases. Plasma lipid peroxide concentration of patients with IHD was 7.24 nmoles MDA/ml (mean), which was reduced to 4.97 nmoles MDA/ml (mean) after 1 year of MAK ‘add-on’ trial. However, no significant reduction was noted in the control group. We conclude that MAK significantly lowers lipid peroxide, which has been implicated in atherogenesis and significantly lowers the incidence of myocardial ischemia.
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