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antioxidant research > antioxidant study 12
Antioxidant
Study #12
Title
In Vitro Inhibition of Microsomal Lipid Peroxidation
by MA-631, Student Rasayana (SR), Ladies Rasayana
(LR), and Maharishi Coffee Substitute (MCS)
Publication
The Pharmacologist, Vol. 34, No. 3, p. 184, 1992
(Abstract).
Authors
H.M. Sharma, A. Hanna, E.M. Kauffman, and H.A.I.
Newman.
Conducted
at
College of Medicine, The Ohio State University,
Columbus, OH 43210
Summary
In this study, the effects of MA-631, SR, LR, and
MCS on microsomal lipid peroxidation were examined
in vitro. Rat liver microsomes were incubated with
a sodium ascorbate and ADP-iron complex or with
an NADPH-generating system to stimulate nonenzymatic
or enzymatic lipid peroxidation, respectively. Aqueous
or alcoholic extracts of MA-631, SR, LR, and MCS,
when added to these incubation systems, inhibited
hepatic microsomal lipid peroxidation in a dose-dependent
manner. The alcoholic extracts were the most effective
antiperoxidants in both systems. The alcoholic extract
of MCS inhibited ascorbate- or NADPH-induced lipid
peroxidation by 56% and 63%, with 12 micrograms
and 22.5 micrograms, respectively. These findings
suggest that these Maharishi Ayurvedaa food supplements
may be useful in the treatment of free radical-induced
injury due to their antiperoxidant properties.
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