Biochemical Archives, Vol. 10, pp. 25-31, 1994.
Stephen C. Bondy, Tina M. Hernandez, and Cara Mattia.
Department of Community and Environmental Medicine, University of California (Irvine), Irvine, CA 92717
This study investigated the antioxidant effects of MAK-4 and MAK-5 in the rat brain in vitro and in vivo. In vitro, ethanol and aqueous extracts of MAK-4 and MAK-5 were able to quench generation of reactive oxygen species within an isolated fraction of rat cerebral cortex enriched in mitochondria and nerve endings (synaptosomes).
In vivo, the excess production of reactive oxygen species observed within the cerebellar mitochondrial fraction after exposure of rats to toluene, was prevented by pretreatment with MAK-5.
For more information on this study, see Research on Reduction of Chemical Toxicity and Antioxidant Research.
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