Title
Priming of Splenic Lymphocytes After Ingestion of an Ayurvedic Herbal Food Supplement [MAK-5]: Evidence for an Immunomodulatory Effect.

Publication
Biochemical Archives, Vol. 6, pp. 267-274, 1990.

Authors
Kottarappat N. Dileepan,* Vimal Patel,** Hari M. Sharma,Ú and Daniel J. Stechschulte.*

Conducted at
**Division of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66103
**Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46223
Ú Department of Pathology, Ohio State University College of Medicine, Columbus, OH 43210

Summary

The in vivo immunomodulatory effects of an Ayurvedic food supplement (Maharishi Amrit Kalash Ambrosia, MAK-5) were studied in rats gavaged with this preparation at a dose of 50 mg/day for 10 or 20 days. After these regimens, mitogen-induced lymphocyte proliferation, macrophage superoxide anion production, and phagocytosis were assayed. In vitro lymphoproliferative responses to various mitogens were markedly enhanced by MAK-5 ingestion. MAK-5-mediated increases in stimulation indices ranged from 32-88% for varying concentrations of phytohemagglutinin (PHA). MAK-5 treatment did not affect spontaneous lymphocyte proliferation. The lymphoproliferative response induced by MAK-5 ingestion was significant even in animals treated for 10 days and persisted for at least 15 days after discontinuation of MAK-5. Macrophage superoxide anion generation and phagocytosis were unaltered as a result of MAK-5 treatment. These data indicate that ingestion of this food supplement enhances lymphocyte responsiveness to mitogens without affecting spontaneous proliferation.

Please Note

MAK-5 is now called Amrit Kalash Ambrosia.


Disclaimer
The sole purpose of these articles is to provide information about the tradition of ayurveda. This information is not intended for use in the diagnosis, treatment, cure or prevention of any disease. If you have any serious acute or chronic health concern, please consult a trained health professional who can fully assess your needs and address them effectively. If you are seeking the medical advice of a trained ayurvedic expert, call or e-mail us for the number of a physician in your area. Check with your doctor before taking herbs or using essential oils when pregnant or nursing.