Japan Journal of Hygiene, Vol. 50, No. 4, pp. 901-905, 1995.
Ryoichi Inaba, Haruo Sugiura, and Hirotoshi Iwata.
Gifu University School of Medicine, Department of Hygiene, Gifu 500, Japan
To evaluate the immunomodulatory effects of two kinds of Ayurvedic food supplements (Maharishi Amrit Kalash 4 and Maharishi Amrit Kalash 5, MAK-4 and MAK-5), superoxide anion production of peritoneal macrophages and the response of spleen cells to concanavalin A (Con A) were examined in mice given an aqueous emulsion of MAK-4 and MAK-5 p.o. at doses of 50 and 100 mg/kg for 10 days. Superoxide anion production of peritoneal macrophages in the MAK-5 (50 mg/kg)-treated group was significantly higher than that in the control group. The indices of stimulation of spleen cells by Con A were significantly (3 to 4 times) higher in groups treated with MAK-4 and MAK-5 at all doses than in the control group. These results indicate that MAK-4 enhances lymphocyte responsiveness and MAK-5 enhances not only lymphocyte responsiveness, but also macrophage function. It is also suggested in this study that MAK-4 and MAK-5 have mitogenic effects on lymphocytes.
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