Indigenous Free Radical Scavenger MAK-4 and MAK-5 in Angina Pectoris. Is it Only a Placebo?

Journal of the Association of Physicians of India, Vol. 42, No. 6, pp. 466-467, 1994.

J. Dogra,* N. Grover,* P. Kumar,* and N. Aneja.**

Conducted at
**Department of Medicine, C.G.H.S., Jaipur, India
**SMS Medical College, Jaipur, India


Thirty patients were evaluated to study the effect of Maharishi Amrit Kalash (MAK-4 and MAK-5) on angina pectoris. The mean angina frequency per month was 8.87. Twelve lead ECG, computerized TMT and echo studies were done initially, at 6 months, and after 2 years in all cases. Ten grams of MAK-4 paste was given daily in two divided doses, each followed by a MAK-5 tablet, for six months. Vasodilator and antihypertensive drugs were continued on ethical grounds. Twenty-four patients (80%) of the total 30 reported a significant improvement after 6 months of therapy. The mean angina frequency per month improved from 8.87 to 3.03 (p<0.001). All patients reported a sense of well-being. Five of 11 hypertensive patients reported a fall in systolic blood pressure. The lipid profile showed a rise in high-density lipoprotein (HDL) which was statistically insignificant. Improved exercise tolerance was observed in 10 cases (33.33%) after 6 months of therapy and this effect was sustained even at 2 years. ECG and echo studies were inconclusive. No side effects or drug interactions were seen. The beneficial effects observed may be the result of the free radical-scavenging property of MAK-4 and MAK-5 on reactive oxygen species (ROS), or an inhibitory effect on lipid peroxidation, or inhibition of platelet aggregation, or all of these in synergism.

Please Note

MAK-4 is now called Amrit Kalash Nectar.
MAK-5 is now called Amrit Kalash Ambrosia.

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