Anti-Oxidant and Antiplatelet Properties of Maharishi Amrit Kalash [MAK-4] in Hypercholesterolemic Rabbits
Ninth International Symposium on Atherosclerosis, Rosemont, IL, October 6-11, 1991, p. 188 (Abstract).
Rao V. Panganamala, Ph.D. and Hari M. Sharma, M.D., FRCP(C).
The Ohio State University, College of Medicine, Columbus, OH, USA
Platelet aggregation and oxidized lipids are considered important mediators of vascular injury leading to atherosclerosis. M-4, an herbal food supplement (MAPI Inc., Lancaster, MA) has been shown to be effective in preventing generation of reactive oxygen species in-vitro (IJCP 1:23-27, 1991). The experiments were carried out to evaluate the effectiveness of M-4 in preventing platelet aggregation and oxidation of lipids in hypercholesterolemic rabbits. Two groups of six rabbits (pair matched) were given a 1% cholesterol diet. The experimental group in addition was given 0.4% M-4 in the diet. At the end of the experiment (7 weeks), total cholesterol, plasma and hepatic TBARS, and platelet aggregation induced by ADP & collagen were compared between the two groups.
The results are
|Total cholesterol (mg/dl)||1511||1003|
|Plasma TBARS (nmoles/ml)||5.38 ± 0.5||1.9 ± 0.3|
|Hepatic TBARS (nmoles/g tissue)||148 ± 16||83 ± 11|
|Platelet Aggregation % Transmittance||Collagen (ug/ml)||ADP (x 10-3)|
|4.4 2.2||4.4 2.2|
|Control (n = 5)||48.6 30.0||34.0 21.0|
|Experimental (n = 4)||26.0 3.0||
Results show that M-4 supplementation reduces plasma and hepatic lipid peroxidation, as well as platelet aggregation induced by collagen and ADP, in hypercholesterolemic rabbits.
The sole purpose of these articles is to provide information about the tradition of ayurveda. This information is not intended for use in the diagnosis, treatment, cure or prevention of any disease. If you have any serious acute or chronic health concern, please consult a trained health professional who can fully assess your needs and address them effectively. If you are seeking the medical advice of a trained ayurvedic expert, call or e-mail us for the number of a physician in your area. Check with your doctor before taking herbs or using essential oils when pregnant or nursing.