Title
Superoxide Scavenging of Two Natural Products, Maharishi-4 [MAK-4] and Maharishi-5 [MAK-5]

Publication
Federation of American Societies for Experimental Biology Journal, Vol. 5, No. 5, p. A1284, 1991 (Abstract).

Authors
Philip F. Tomlinson, Jr. and Robert Keith Wallace (SPON: J. Fagan).

Conducted at
Department of Physiological and Biological Sciences, Maharishi International University, Fairfield, IA 52556

Summary

Maharishi Ayurveda, a recent restoration of the traditional health care system of India, upholds an herbal fruit concentrate (M-4) and an herbal tablet (M-5) as rasayanas—food supplements that promote physiological balance, health, and immunity. The superoxide scavenging properties of M-4, M-5, and ascorbic acid were investigated with superoxide radicals generated during the catalytic activity of xanthine oxidase. M-4 and M-5 (10 mg/ml prior to centrifugation) inhibited the reduction of nitroblue tetrazolium (NBT) 98% and 96%, respectively. 50% inhibition of NBT reduction was obtained with 0.04 mg/ml M-4 and 0.15 mg/ml M-5. Ascorbic acid inhibition of superoxide radical reduction of NBT reached 88% at 1 mM, but declined to 42% at a concentration of 10 mM. The rate of uric acid production monitored at 290 nm demonstrated negligible inhibition of xanthine oxidase by M-4, M-5, or ascorbic acid. The results contribute to an understanding of previously reported antineoplastic, antioxidant, and anti-aging properties of M-4 and M-5, and warrant consideration in the light of present preventive, nutritional, and chemotherapeutic approaches to health, antioxidant defense, and carcinogenesis.

Please Note

MAK-4 is now called Amrit Kalash Nectar.
MAK-5 is now called Amrit Kalash Ambrosia.


Disclaimer
The sole purpose of these articles is to provide information about the tradition of ayurveda. This information is not intended for use in the diagnosis, treatment, cure or prevention of any disease. If you have any serious acute or chronic health concern, please consult a trained health professional who can fully assess your needs and address them effectively. If you are seeking the medical advice of a trained ayurvedic expert, call or e-mail us for the number of a physician in your area. Check with your doctor before taking herbs or using essential oils when pregnant or nursing.