Protective Effects of MAK-4 and MAK-5 on Adriamycin-Induced Microsomal Lipid Peroxidation and Mortality
Biochemical Archives, Vol. 8, pp. 267-272, 1992.
Ferzaan N. Engineer,* Hari M. Sharma,** and Chandradhar Dwivedi.*
*College of Pharmacy, South Dakota State University, Brookings, SD
**College of Medicine, The Ohio State University, Columbus, OH
The clinical usefulness of the chemotherapeutic agent Adriamycin is compromised by dose-dependent and potentially lethal cardiac toxic effects. The cardiotoxicity of Adriamycin may be linked with free radical-mediated peroxidation of microsomal lipids. This study examined the effects of MAK-4 and MAK-5, herbal food supplements, on Adriamycin-induced lipid peroxidation and toxicity. Rat liver microsomes were incubated with an NADPH-generating system to stimulate lipid peroxidation in the presence or absence of Adriamycin. Alcoholic or aqueous extracts of MAK-4 and MAK-5, when added to these incubation systems, inhibited hepatic microsomal lipid peroxidation in a concentration-dependent manner. The 10% ethanolic or aqueous extract of MAK-4 was a highly effective inhibitor of lipid peroxidation. The ethanolic extract (10%) of MAK-5 also inhibited lipid peroxidation. However, the 10% aqueous extract of MAK-5 did not exhibit antiperoxidant properties under these experimental conditions.
See Cancer Research for more information on this study.
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