Title
Protective Effects of MAK-4 and MAK-5 on Adriamycin-Induced Microsomal Lipid Peroxidation and Mortality

Publication
Biochemical Archives, Vol. 8, pp. 267-272, 1992.

Authors
Ferzaan N. Engineer,* Hari M. Sharma,** and Chandradhar Dwivedi.*

Conducted at
*College of Pharmacy, South Dakota State University, Brookings, SD
**College of Medicine, The Ohio State University, Columbus, OH

Summary

The clinical usefulness of the chemotherapeutic agent Adriamycin is compromised by dose-dependent and potentially lethal cardiac toxic effects. The cardiotoxicity of Adriamycin may be linked with free radical-mediated peroxidation of microsomal lipids. This study examined the effects of MAK-4 and MAK-5, herbal food supplements, on Adriamycin-induced lipid peroxidation and toxicity. Rat liver microsomes were incubated with an NADPH-generating system to stimulate lipid peroxidation in the presence or absence of Adriamycin. Alcoholic or aqueous extracts of MAK-4 and MAK-5, when added to these incubation systems, inhibited hepatic microsomal lipid peroxidation in a concentration-dependent manner. The 10% ethanolic or aqueous extract of MAK-4 was a highly effective inhibitor of lipid peroxidation. The ethanolic extract (10%) of MAK-5 also inhibited lipid peroxidation. However, the 10% aqueous extract of MAK-5 did not exhibit antiperoxidant properties under these experimental conditions.

See Cancer Research for more information on this study.

Please Note

MAK-4 is now called Amrit Kalash Nectar.
MAK-5 is now called Amrit Kalash Ambrosia.


Disclaimer
The sole purpose of these articles is to provide information about the tradition of ayurveda. This information is not intended for use in the diagnosis, treatment, cure or prevention of any disease. If you have any serious acute or chronic health concern, please consult a trained health professional who can fully assess your needs and address them effectively. If you are seeking the medical advice of a trained ayurvedic expert, call or e-mail us for the number of a physician in your area. Check with your doctor before taking herbs or using essential oils when pregnant or nursing.