Title
Inhibition of Human Low-Density Lipoprotein Oxidation In Vitro by Maharishi Ayurveda Herbal Mixtures [MAK-4, MAK-5, MA-631, and Maharishi Coffee Substitute]

Publication
Pharmacology, Biochemistry and Behavior, Vol. 43, pp. 1175-1182, 1992.

Authors
Hari M. Sharma, Atef N. Hanna, Ellen M. Kauffman, and Howard A.I. Newman.

Conducted at
Department of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210

Summary

This study examined the effect of the Maharishi Ayurvedaa herbal mixtures (MAHMs) MAK-4, MAK-5, MA-631, and Maharishi Coffee Substitute (MCS) on low-density lipoprotein (LDL) oxidation, and compared the potency of these mixtures to ascorbic acid (vitamin C), alpha-tocopherol (vitamin E), and the drug probucol. LDL was incubated in 95% air and 5% CO2, with or without 3 micromolar Cu+2, in the presence or absence of alcoholic or aqueous extracts of MAHMs, for 6 or 24 hours. In a separate experiment, LDL was incubated as above except the MAHM extracts were added at 0, 1.5, and 3.5 hours after incubation started, to assess their effect on the initiation and propagation of LDL oxidation. The results demonstrate that MAHMs caused concentration-dependent inhibition of LDL oxidation as assessed by thiobarbituric acid-reactive substances (TBARS) and electrophoretic mobility. Both the aqueous and alcoholic extracts of the MAHMs showed more antioxidant potency in preventing LDL oxidation than ascorbic acid, alpha-tocopherol, or probucol. The alcoholic extracts of the MAHMs were at least 1000 times more potent than ascorbic acid, alpha-tocopherol, and probucol after the 6-hour incubation. The alcoholic extracts of the MAHMs showed an even larger magnitude of difference after the 24-hour incubation. Also, the MAHMs inhibited both the initiation and propagation of cupric ion-catalyzed LDL oxidation.

Please Note

MAK-4 is now called Amrit Kalash Nectar.
MAK-5 is now called Amrit Kalash Ambrosia.
MA-631 is now called Rejuvenation for Men.
Maharishi Coffee Substitute is now called Raja's Cup.


Disclaimer
The sole purpose of these articles is to provide information about the tradition of ayurveda. This information is not intended for use in the diagnosis, treatment, cure or prevention of any disease. If you have any serious acute or chronic health concern, please consult a trained health professional who can fully assess your needs and address them effectively. If you are seeking the medical advice of a trained ayurvedic expert, call or e-mail us for the number of a physician in your area. Check with your doctor before taking herbs or using essential oils when pregnant or nursing.