Title
Effect of Maharishi 4 [MAK-4] and Maharishi 5 [MAK-5] on Inflammatory Mediators—With Special Reference to Their Free Radical Scavenging Effect

Publication
Indian Journal of Clinical Practice, Vol. 1, No. 8, pp. 23-27, January 1991.

Author
Yukie Niwa.

Conducted at
Niwa Institute for Immunology, Japan

Summary

Maharishi 4 (MAK-4) and Maharishi 5 (MAK-5) were investigated for their effects on human neutrophil chemotaxis, phagocytosis, reactive oxygen species (ROS) generation, and lymphocyte response to mitogens. The effect on ROS generated in a xanthine-xanthine oxidase system was also tested. Chemotaxis was significantly inhibited in the presence of MAK-4 and phagocytosis was slightly decreased in the presence of both MAK-4 and MAK-5. MAK-4 and MAK-5 markedly decreased superoxide, hydrogen peroxide, and hydroxyl radicals, generated both in the neutrophil and xanthine-xanthine oxidase systems. These two herbal mixtures also significantly reduced lymphocyte blastogenesis stimulated by the mitogens phytohemagglutinin, concanavalin A, and pokeweed mitogen. This study suggests that the empirical effectiveness of these two natural products in a variety of diseases is due to their suppressive effect on inflammatory mediators, especially on potent ROS.

Please Note

MAK-4 is now called Amrit Kalash Nectar.
MAK-5 is now called Amrit Kalash Ambrosia.


Disclaimer
The sole purpose of these articles is to provide information about the tradition of ayurveda. This information is not intended for use in the diagnosis, treatment, cure or prevention of any disease. If you have any serious acute or chronic health concern, please consult a trained health professional who can fully assess your needs and address them effectively. If you are seeking the medical advice of a trained ayurvedic expert, call or e-mail us for the number of a physician in your area. Check with your doctor before taking herbs or using essential oils when pregnant or nursing.