Effect of Maharishi 4 [MAK-4] and Maharishi 5 [MAK-5] on Inflammatory MediatorsWith Special Reference to Their Free Radical Scavenging Effect
Indian Journal of Clinical Practice, Vol. 1, No. 8, pp. 23-27, January 1991.
Niwa Institute for Immunology, Japan
Maharishi 4 (MAK-4) and Maharishi 5 (MAK-5) were investigated for their effects on human neutrophil chemotaxis, phagocytosis, reactive oxygen species (ROS) generation, and lymphocyte response to mitogens. The effect on ROS generated in a xanthine-xanthine oxidase system was also tested. Chemotaxis was significantly inhibited in the presence of MAK-4 and phagocytosis was slightly decreased in the presence of both MAK-4 and MAK-5. MAK-4 and MAK-5 markedly decreased superoxide, hydrogen peroxide, and hydroxyl radicals, generated both in the neutrophil and xanthine-xanthine oxidase systems. These two herbal mixtures also significantly reduced lymphocyte blastogenesis stimulated by the mitogens phytohemagglutinin, concanavalin A, and pokeweed mitogen. This study suggests that the empirical effectiveness of these two natural products in a variety of diseases is due to their suppressive effect on inflammatory mediators, especially on potent ROS.
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