Effect of Herbal Mixture Student Rasayana on Lipoxygenase Activity and Lipid Peroxidation
Free Radical Biology and Medicine, Vol. 18, No. 4, pp. 687-697, 1995.
Hari M. Sharma, Atef N. Hanna, Ellen M. Kauffman, and Howard A.I. Newman.
Department of Pathology, College of Medicine, The Ohio State University, Columbus, OH
Brain cellular functions are affected by free radicals. Arachidonic acid and its 12-lipoxygenase metabolites have been proposed as important in enhancing long-term potentiation associated with learning. It has been reported that Student Rasayana (SR), an herbal mixture, improves brain functions. This study evaluated the antioxidant capacity of SR and its effect on lipoxygenase activity. Both the alcoholic and aqueous extracts of SR inhibited enzymatic- and nonenzymatic-induced microsomal lipid peroxidation in a concentration-dependent manner (p<0.05). The agent concentrations (microgram/mL) that produced 50% inhibition (IC50) of enzymatic- and nonenzymatic-induced microsomal lipid peroxidation, respectively, were 99.1 +/- 3.9 and 1992.0 +/- 122.7 for the aqueous extract, and 17.7 +/- 0.9 and 646.7 +/- 79.7 for the alcoholic extract. The aqueous extract inhibited soyabean lipoxygenase (SLP)-induced LDL oxidation in a concentration-dependent manner (IC50: 515.5 +/- 11.5) (p<0.05), whereas the alcoholic extract enhanced SLP-induced LDL oxidation. Simultaneous addition of the aqueous and alcoholic extracts inhibited SLP-induced LDL oxidation (p<0.05). The alcoholic extract (but not the aqueous extract) enhanced the ability of SLP to induce oxidation of linoleic acid. These results suggest SR improves brain functions through scavenging free radicals as well as increasing the second messenger for long-term potentiation.
See Research on Reduction of Chemical Toxicity and Research on Neurophysiology and Intelligence for more information on this study.
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