Antioxidant and Antiplatelet Properties of Maharishi Amrit Kalash [MAK-4] in Hypercholesterolemic Rabbits
Ninth International Symposium on Atherosclerosis, Rosemont, IL, October 6-11, 1991, p. 188 (Abstract).
Rao V. Panganamala, Ph.D. and Hari M. Sharma, M.D., FRCP(C).
The Ohio State University, College of Medicine, Columbus, OH, USA
Platelet aggregation and oxidized lipids are considered important mediators of vascular injury leading to atherosclerosis. M-4, an herbal food supplement (MAPI Inc., Lancaster, MA) has been shown to be effective in preventing generation of reactive oxygen species in-vitro (IJCP 1:23-27, 1991). The experiments were carried out to evaluate the effectiveness of M-4 in preventing platelet aggregation and oxidation of lipids in hypercholesterolemic rabbits. Two groups of six rabbits (pair matched) were given a 1% cholesterol diet. The experimental group in addition was given 0.4% M-4 in the diet. At the end of the experiment (7 weeks) total cholesterol, plasma and hepatic TBARS and platelet aggregation induced by ADP & collagen were compared between the two groups.
|The results are:|
|Total cholesterol (mg/dl)||1511||1003|
Plasma TBARS (nmoles/ml)
|5.38 + 0.5||1.9 + 0.3|
|Hepatic TBARS (nmoles/g tissue)||148 + 16||83 + 11|
|Platelet Aggregation % Transmittance||Collagen (ug/ml)||ADP (x 10-3)|
|4.4 2.2||4.4 2.2|
|Control (n = 5)||48.6 30.0||34.0 21.0|
|Experimental (n = 4)
||26.0 3.0||10.0 3.75|
Results show that M-4 supplementation reduces plasma and hepatic lipid peroxidation and platelet aggregation induced by collagen and ADP in hypercholesterolemic rabbits.
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