Effect of Herbal Mixture Student Rasayana on Lipoxygenase Activity and Lipid Peroxidation
Free Radical Biology and Medicine, Vol. 18, No. 4, pp. 687-697, 1995.
Hari M. Sharma, Atef N. Hanna, Ellen M. Kauffman, and Howard A.I. Newman.
Department of Pathology, College of Medicine, The Ohio State University, Columbus, OH
There is evidence that suggests a relationship among free radicals, brain injury, and brain functionality. The scavenging of free radicals as a possible mechanism for the improvement in intelligence by Student Rasayana (SR) was explored in this study on the effect of SR on lipid peroxidation and lipoxygenase activity. SR inhibited enzymatic- and nonenzymatic-induced rat liver microsomal lipid peroxidation in a concentration-dependent manner (p<0.05). SR also inhibited soyabean lipoxygenase-induced LDL oxidation in vitro (p<0.05). In vivo, SR inhibited toluene-induced rat brain microsomal lipid peroxidation (p<0.05). An interesting finding in this study is that an alcoholic extract of SR increased in vitro a metabolite of arachidonic acid which enhances long-term potentiation, a process associated with learning. Thus, SR may protect brain functions and increase intelligence through scavenging of free radicals and/or increasing certain metabolites of arachidonic acid.
For more information on this study, see Research on Reduction of Chemical Toxicity and Antioxidant Research.
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