Title
Anti-Aging and Oxygen Free Radical (OFR) Scavenging Effects of an Anti-Carcinogenic Natural Product, Maharishi Amrit Kalash [MAK-4 and MAK-5]

Publication
Federation of American Societies for Experimental Biology Journal, Vol. 5, No. 6, p. A1735, 1991 (Abstract).

Authors
J.Z. Fields, E. Eftekhari, J.F. Hagen, L.J. Wichlinski, and R.H. Schneider (SPON: A.H. Friedman).

Conducted at
Research Service 151, VA Hosp., Hines, IL 60141
Dept. of Pharmacology, Loyola Univ. Med. Sch., Maywood, IL
Dept. of Physiology, Maharishi International University, Fairfield, IA

Summary

MAK is an herbal preparation available as a food supplement. It is being taken for its anticipated health-promoting and anti-aging benefits. MAK refers to the combination of two natural products: M4 a paste, and M5 a tablet. Combined, MAK is comprised of plants or plant parts from 24 different herbs. Sharma et al. (Pharmacol Biochem Behav, 35:767–773, 1990) showed that MAK prevents and even reverses chemically induced breast tumors in rats. We showed (JZ Fields et al, The Pharmacologist, 32:155, 1990) that aqueous extracts of MAK scavenged both OFR (superoxide) and non-radical oxidants (hypochlorous acid) in suspensions of human neutrophils without compromising the viability of the cells. In mice (C57BL/6 male, n=29/group) fed 6% MAK in the diet starting at 18 months of age, 80% of MAK mice were alive at 23 mo vs. 48% for controls (p<0.05). Body weights for control (41.5 g) and MAK mice (38.3 g) were not significantly different. In fruitflies (male, wild type, Drosophila melanogaster, n=100/group) fed 12% MAK from hatching to expiration, mean life span was significantly increased (+70%). The antioxidant properties and anti-carcinogenic properties of MAK may contribute to its anti-aging properties.

Please Note

MAK-4 is now called Amrit Kalash Nectar.
MAK-5 is now called Amrit Kalash Ambrosia.


Disclaimer
The sole purpose of these articles is to provide information about the tradition of ayurveda. This information is not intended for use in the diagnosis, treatment, cure or prevention of any disease. If you have any serious acute or chronic health concern, please consult a trained health professional who can fully assess your needs and address them effectively. If you are seeking the medical advice of a trained ayurvedic expert, call or e-mail us for the number of a physician in your area. Check with your doctor before taking herbs or using essential oils when pregnant or nursing.