Effect of Maharishi Amrit Kalash, an Ayurvedic Herbal Mixture, on Lipid Peroxidation and Neuronal Lipofuscin Accumulation in Aging Guinea Pig Brain

Indian Journal of Experimental Biology, Vol. 39, No. 4, pp. 355-359, 2001.

B.P. Vohra, S.P. Sharma, V.K. Kansal, and S.K. Gupta.

Conducted at
Laboratory of Nutritional Histopathology, Kurukshetra University, India


The effects of Ayurvedic herbal mixture Maharishi Amrit Kalash (MAK) were studied on brain lipid peroxidation, oxygen consumption, and lipofuscin accumulation in 10-month-old and 32-month-old guinea pigs. Brain regions studied were cerebral cortex, hypothalamus, cerebellum and spinal cord. Parameters assessed were lipid peroxidation, oxygen consumption, and lipofuscin accumulation. The endogenous lipid peroxide was found to be increased significantly (p<0.05) in the 32-month-old animals. Neuronal lipofuscin accumulation in the neurons of cerebral motor cortex, cerebellum and cervical spinal cord was increased (p<0.05) in the older animals. Oxygen consumption was found to be decreased significantly (p<0.05) in the 32-month-old guinea pigs. Treatment with MAK at a dose of 500 mg/kg body weight daily for two months reduced the lipid peroxidation and lipofuscin pigment accumulation significantly in brain regions, and it also helped in restoring the normal oxygen consumption in the older animals. This indicates antioxidant properties of MAK.

Abstract reprinted by permission of the publisher from Indian Journal of Experimental Biology, Vol. 39, No. 4, pp. 355-359, 2001.

The sole purpose of these articles is to provide information about the tradition of ayurveda. This information is not intended for use in the diagnosis, treatment, cure or prevention of any disease. If you have any serious acute or chronic health concern, please consult a trained health professional who can fully assess your needs and address them effectively. If you are seeking the medical advice of a trained ayurvedic expert, call or e-mail us for the number of a physician in your area. Check with your doctor before taking herbs or using essential oils when pregnant or nursing.